Creatine may slow the progression of ALS by boosting energy supplies to weakening muscles and deteriorating motor nerves. A metabolic supplement, many atheletes take creatine to increase muscle strength.
We think that creatine may be moderately beneficial in people with ALS. A phase III clinical trial is ongoing.
There is no clear evidence that any one dietary supplement or combination of supplements promotes disease reversal or prolongs survival.
Creatine did not significantly improve function or survival according to 3 trials of 386 patients.
Creatine appears safe but ineffective in a double-blind placebo-controlled trial of 104 ALS patients.
Design, power and interpretation (ALS Journal)
The purpose of this study is to determine whether nine months of administration of creatine monohydrate results in an increase in muscle strength in patients with amyotrophic lateral sclerosis (ALS).